Original Research Open access Published: 28 Apr 2026

SGLT2 inhibitors and progression of moderate calcific aortic stenosis: Protocol for a prospective multicentre cohort study (SLOW-AS)

Klaus Weber, Eugene Braunwald, Walter E. Desai

¹ TIMI Study Group, Division of Cardiology, Brigham and Women’s Hospital, Boston, Massachusetts, USA
² Miller Family Heart, Vascular & Thoracic Institute, Cleveland Clinic, Cleveland, Ohio, USA.

Journal of Experimental & Integrative Medicine volume 14 pages 11-20 (2026)

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Received 19 Jul 2025 Accepted 2 Apr 2026 Published 28 Apr 2026 License CC BY 4.0

Keywords: Aortic stenosis; calcific aortic valve disease; SGLT2 inhibitors; disease progression; echocardiography; cardiac damage staging

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Weber, K., Braunwald, E. & Desai, W. E. SGLT2 inhibitors and progression of moderate calcific aortic stenosis: Protocol for a prospective multicentre cohort study (SLOW-AS). J. Exp. Integr. Med. 14, 11–20 (2026). https://www.jeim.org/articles/2614207

Weber, K., Braunwald, E., & Desai, W. E. (2026). SGLT2 inhibitors and progression of moderate calcific aortic stenosis: Protocol for a prospective multicentre cohort study (SLOW-AS). Journal of Experimental & Integrative Medicine, 14(2), 11–20. https://www.jeim.org/articles/2614207

Klaus Weber, et al.. "SGLT2 inhibitors and progression of moderate calcific aortic stenosis: Protocol for a prospective multicentre cohort study (SLOW-AS)." Journal of Experimental & Integrative Medicine, vol. 14, no. 2, 2026, pp. 11–20, https://www.jeim.org/articles/2614207.

Klaus Weber, Eugene Braunwald, Walter E. Desai. "SGLT2 inhibitors and progression of moderate calcific aortic stenosis: Protocol for a prospective multicentre cohort study (SLOW-AS)." Journal of Experimental & Integrative Medicine 14, no. 2 (2026): 11–20. https://www.jeim.org/articles/2614207.

Weber K, Braunwald E, Desai WE. SGLT2 inhibitors and progression of moderate calcific aortic stenosis: Protocol for a prospective multicentre cohort study (SLOW-AS). J. Exp. Integr. Med.. 2026;14(2):11-20. Available from: https://www.jeim.org/articles/2614207

@article{eber2026sglt2inhibitors,
  title = {SGLT2 inhibitors and progression of moderate calcific aortic stenosis: Protocol for a prospective multicentre cohort study (SLOW-AS)},
  author = {Weber, Klaus and Braunwald, Eugene and Desai, Walter E.},
  journal = {Journal of Experimental & Integrative Medicine},
  year = {2026},
  volume = {14},
  number = {2},
  pages = {11--20},
  url = {https://www.jeim.org/articles/2614207},
}