U-47700 is a potent synthetic opioid that has emerged as a significant contributor to drugrelated toxicity and overdose deaths. Despite increasing reports of clinical intoxication, little information is available regarding its pharmacokinetic profile and metabolic pathways in humans. This study investigates the pharmacokinetics and metabolism of U-47700 using analytical toxicology techniques and pharmacokinetic modeling. Blood and urine
samples from suspected exposure cases were analyzed using liquid chromatography–tandem
mass spectrometry. Results suggest rapid systemic absorption, hepatic metabolism, and
a relatively short elimination half-life. Several metabolites were identified, indicating
extensive biotransformation. Understanding these processes is essential for improving clinical management of overdoses and enhancing forensic detection methods.
