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Current issues with paracetamol induced toxicity

Halil Yaman, Salim Isbilir, Erdinc Cakir, Bulent Uysal.

Cited by (11)

Abstract
Paracetamol (acetaminophen; APAP), a commonly-used analgesic and anti-pyretic drug, is usually safe when administered at therapeutic doses in children. However, at overdoses, APAP has the potential for causing fulminant hepatic necrosis and nephrotoxicity in both humans and animals. In pre-school children, many poisonings are due to chemical or pharmaceutical preparations like APAP which is an important example for poisoning with pharmaceutics.
Liver has an important role in the metabolism of toxic chemicals, certain drugs and environmental pollutants. Using the cytochrome P450 pathway, APAP is converted to a highly toxic metabolite, namely N–acetyl–p–benzoquinamine (NAPQI). By this way, ...

Key words: Acetaminophen; Hepatotoxicity; Herbal agents; Nephrototoxicity


 
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How to Cite this Article
Pubmed Style

Yaman H, Isbilir S, Cakir E, Uysal B. Current issues with paracetamol induced toxicity. J Exp Integr Med. 2011; 1(3): 165-166. doi:10.5455/jeim.010711.ed.005



Web Style

Yaman H, Isbilir S, Cakir E, Uysal B. Current issues with paracetamol induced toxicity. www.scopemed.org/?mno=8747 [Access: June 26, 2017]. doi:10.5455/jeim.010711.ed.005



AMA (American Medical Association) Style

Yaman H, Isbilir S, Cakir E, Uysal B. Current issues with paracetamol induced toxicity. J Exp Integr Med. 2011; 1(3): 165-166. doi:10.5455/jeim.010711.ed.005



Vancouver/ICMJE Style

Yaman H, Isbilir S, Cakir E, Uysal B. Current issues with paracetamol induced toxicity. J Exp Integr Med. (2011), [cited June 26, 2017]; 1(3): 165-166. doi:10.5455/jeim.010711.ed.005



Harvard Style

Yaman, H., Isbilir, S., Cakir, E. & Uysal, B. (2011) Current issues with paracetamol induced toxicity. J Exp Integr Med, 1 (3), 165-166. doi:10.5455/jeim.010711.ed.005



Turabian Style

Yaman, Halil, Salim Isbilir, Erdinc Cakir, and Bulent Uysal. 2011. Current issues with paracetamol induced toxicity. Journal of Experimental and Integrative Medicine, 1 (3), 165-166. doi:10.5455/jeim.010711.ed.005



Chicago Style

Yaman, Halil, Salim Isbilir, Erdinc Cakir, and Bulent Uysal. "Current issues with paracetamol induced toxicity." Journal of Experimental and Integrative Medicine 1 (2011), 165-166. doi:10.5455/jeim.010711.ed.005



MLA (The Modern Language Association) Style

Yaman, Halil, Salim Isbilir, Erdinc Cakir, and Bulent Uysal. "Current issues with paracetamol induced toxicity." Journal of Experimental and Integrative Medicine 1.3 (2011), 165-166. Print. doi:10.5455/jeim.010711.ed.005



APA (American Psychological Association) Style

Yaman, H., Isbilir, S., Cakir, E. & Uysal, B. (2011) Current issues with paracetamol induced toxicity. Journal of Experimental and Integrative Medicine, 1 (3), 165-166. doi:10.5455/jeim.010711.ed.005