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Protective effect of Pisonia aculeata on paracetamol induced hepatotoxicity in rats

Chinnasamy Anbarasu, Balasubramanium Rajkapoor, Jayapalu Kalpana.

Cited by (3)

Abstract
Objective: Pisonia aculeata, is traditionally used in treatment of liver disorder and thought to have a protective effect which may be beneficial to reduce symptoms of hepatotoxicity. The current study evaluated the scientific merit of these anecdotal claims in an in vivo model.
Method: Male Wistar rats were administered 250 or 500 mg/kg of Pisonia aculeata extract for 21 days and simultaneously administered paracetamol 750 mg/kg every 72 h by daily oral gavage. At the end of all experimental methods, all the animals were sacrificed by cervical decapitation. Blood samples were collected. Serum was separated and analyzed for various biochemical parameters.
Results: The plant extract showed a remarkable hepatoprotective and antioxidant activity against paracetamol induced hepatotoxicity as judged from the serum marker enzymes and antioxidant levels in liver tissues. Paracetamol induced a significant rise in aspartate amino transferase (AST), alanine amino transferase (ALT), alkaline phosphatase (ALP), total bilirubin, gamma glutamate transpeptidase (GGTP), lipid peroxides (LPO) with a reduction of total protein, superoxide dismutase (SOD), catalase, glutathione peroxidase (GPx) and glutathione S-transferase (GST).
Conclusion: Treatment of rats with different doses of plant extract significantly altered serum marker enzymes and antioxidant levels to near normal. The efficacy of the extract at dose of 300 mg/kg was comparable to the standard drug silymarin (50 mg/kg, p.o.). Data indicates a positive effect. More research is required to derive an optimal therapeutic dose.

Key words: Antioxidants; Histopathology; Lipid peroxidation; Paracetamol; Pisonia aculeata


 
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How to Cite this Article
Pubmed Style

Anbarasu C, Rajkapoor B, Kalpana J. Protective effect of Pisonia aculeata on paracetamol induced hepatotoxicity in rats. J Exp Integr Med. 2011; 1(3): 167-172. doi:10.5455/jeim.040511.or.008



Web Style

Anbarasu C, Rajkapoor B, Kalpana J. Protective effect of Pisonia aculeata on paracetamol induced hepatotoxicity in rats. www.scopemed.org/?mno=5790 [Access: June 26, 2017]. doi:10.5455/jeim.040511.or.008



AMA (American Medical Association) Style

Anbarasu C, Rajkapoor B, Kalpana J. Protective effect of Pisonia aculeata on paracetamol induced hepatotoxicity in rats. J Exp Integr Med. 2011; 1(3): 167-172. doi:10.5455/jeim.040511.or.008



Vancouver/ICMJE Style

Anbarasu C, Rajkapoor B, Kalpana J. Protective effect of Pisonia aculeata on paracetamol induced hepatotoxicity in rats. J Exp Integr Med. (2011), [cited June 26, 2017]; 1(3): 167-172. doi:10.5455/jeim.040511.or.008



Harvard Style

Anbarasu, C., Rajkapoor, B. & Kalpana, J. (2011) Protective effect of Pisonia aculeata on paracetamol induced hepatotoxicity in rats. J Exp Integr Med, 1 (3), 167-172. doi:10.5455/jeim.040511.or.008



Turabian Style

Anbarasu, Chinnasamy, Balasubramanium Rajkapoor, and Jayapalu Kalpana. 2011. Protective effect of Pisonia aculeata on paracetamol induced hepatotoxicity in rats. Journal of Experimental and Integrative Medicine, 1 (3), 167-172. doi:10.5455/jeim.040511.or.008



Chicago Style

Anbarasu, Chinnasamy, Balasubramanium Rajkapoor, and Jayapalu Kalpana. "Protective effect of Pisonia aculeata on paracetamol induced hepatotoxicity in rats." Journal of Experimental and Integrative Medicine 1 (2011), 167-172. doi:10.5455/jeim.040511.or.008



MLA (The Modern Language Association) Style

Anbarasu, Chinnasamy, Balasubramanium Rajkapoor, and Jayapalu Kalpana. "Protective effect of Pisonia aculeata on paracetamol induced hepatotoxicity in rats." Journal of Experimental and Integrative Medicine 1.3 (2011), 167-172. Print. doi:10.5455/jeim.040511.or.008



APA (American Psychological Association) Style

Anbarasu, C., Rajkapoor, B. & Kalpana, J. (2011) Protective effect of Pisonia aculeata on paracetamol induced hepatotoxicity in rats. Journal of Experimental and Integrative Medicine, 1 (3), 167-172. doi:10.5455/jeim.040511.or.008