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Review Article Open Access


Immunomodulatory activities of five clinically used Chinese herbal polysaccharides

Xiaojuan He, Xuyan Niu, Jian Li, Shaohua Xu, Aiping Lu.

Cited by (13)

Abstract
Polysaccharide is a natural macromolecular compound with complex, important and multifaceted biological activities. Some of polysaccharides have been marketed in China as drugs or healthy products.
More studies confirm that the active ingredient of many traditional Chinese medicine exist in the form of polysaccharides. They play a role in disease therapy by activating immune cells and the complement system; regulating the cytokines expression; promoting the production of antibodies; inhibiting tumor cell proliferation and inducing tumor cell apoptosis; inhibiting virus entering cells and replication; increasing activity of antioxidant enzyme; scavenging free radicals; and inhibiting lipid peroxidation.
In this review, we focus on the immunomodulatory effects and its possible mechanism of polysaccharides from Chinese herbal polysaccharides products, including Lentinan, Astragalus polysaccharide, Polyporus polysaccharide and Achyranthes bidentata polysaccharide. The immunomodulatory activities of polysaccharides were categorized in the paper into general immunoregulatory activity, anti-tumor, anti-infections, anti-inflammatory, anti-oxidative, anti-mutagenic and radioprotective, anti-complementary, anti-adhesive, and anti-allergy since all the activities are related to modulate immune responses by the polysaccharides. Also the challenges in the research of polysaccharides will be discussed.

Key words: Chinese herbal medicine; Immunomodulatory activity; Polysaccharides


 
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How to Cite this Article
Pubmed Style

He X, Niu X, Li J, Xu S, Lu A. Immunomodulatory activities of five clinically used Chinese herbal polysaccharides. J Exp Integr Med. 2012; 2(1): 15-27. doi:10.5455/jeim.211211.rw.004



Web Style

He X, Niu X, Li J, Xu S, Lu A. Immunomodulatory activities of five clinically used Chinese herbal polysaccharides. www.scopemed.org/?mno=10286 [Access: June 26, 2017]. doi:10.5455/jeim.211211.rw.004



AMA (American Medical Association) Style

He X, Niu X, Li J, Xu S, Lu A. Immunomodulatory activities of five clinically used Chinese herbal polysaccharides. J Exp Integr Med. 2012; 2(1): 15-27. doi:10.5455/jeim.211211.rw.004



Vancouver/ICMJE Style

He X, Niu X, Li J, Xu S, Lu A. Immunomodulatory activities of five clinically used Chinese herbal polysaccharides. J Exp Integr Med. (2012), [cited June 26, 2017]; 2(1): 15-27. doi:10.5455/jeim.211211.rw.004



Harvard Style

He, X., Niu, X., Li, J., Xu, S. & Lu, A. (2012) Immunomodulatory activities of five clinically used Chinese herbal polysaccharides. J Exp Integr Med, 2 (1), 15-27. doi:10.5455/jeim.211211.rw.004



Turabian Style

He, Xiaojuan, Xuyan Niu, Jian Li, Shaohua Xu, and Aiping Lu. 2012. Immunomodulatory activities of five clinically used Chinese herbal polysaccharides. Journal of Experimental and Integrative Medicine, 2 (1), 15-27. doi:10.5455/jeim.211211.rw.004



Chicago Style

He, Xiaojuan, Xuyan Niu, Jian Li, Shaohua Xu, and Aiping Lu. "Immunomodulatory activities of five clinically used Chinese herbal polysaccharides." Journal of Experimental and Integrative Medicine 2 (2012), 15-27. doi:10.5455/jeim.211211.rw.004



MLA (The Modern Language Association) Style

He, Xiaojuan, Xuyan Niu, Jian Li, Shaohua Xu, and Aiping Lu. "Immunomodulatory activities of five clinically used Chinese herbal polysaccharides." Journal of Experimental and Integrative Medicine 2.1 (2012), 15-27. Print. doi:10.5455/jeim.211211.rw.004



APA (American Psychological Association) Style

He, X., Niu, X., Li, J., Xu, S. & Lu, A. (2012) Immunomodulatory activities of five clinically used Chinese herbal polysaccharides. Journal of Experimental and Integrative Medicine, 2 (1), 15-27. doi:10.5455/jeim.211211.rw.004